FLIPR Penta High-Throughput Cellular Screening System from Molecular Devices LLC

Product Specs
ItemFLIPR Penta High-Throughput Cellular Screening System
CompanyMolecular Devices LLC
Price Get Pricing Get Quote for this Product
Catalog NumberFLIPR PENTA
QuantityEA
DetectionLuminescence and Fluorescence
Plate Formats96, 384, and 1536-well plates
Wavelength(s)400 to 750 nM
Dimensions(WxDxH) 39 x 27 x 70 in. (or 99 x 69 x 178 cm)
Measuring Time2-minute read time
Throughput20 plates/hour
CameraEMCCD (HS-EMCCD optional)
Temperature Range[RT + 5°C] to 40°C
Optical SystemFilter (3-position slider)
ApplicationsLuminescence, Fluorescence, Calcium Flux, Cardiomyocyte screening, Cardiotoxicity, GPCRs (G protein-coupled receptors), Ion Channel, Membrane Potential, Neuronal assays, Potassium Assays

Specifications/Features

Temperature control; User-changeable pipette modules

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Molecular Devices LLC

3860 N First Street

San Jose, California 95134

United States

Phone: 408-747-1700

Company Profile

Website: http://www.moleculardevices.com/

(1) Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microgliaScientific ReportsNovember 22, 2023Nina Stöberl, Jasmine Donaldson, Caroline S. Binda, Branduff McAllister, Hazel Hall-Roberts, Lesley Jones, Thomas H. Massey, Nicholas D. AllenμM Ionomycin (Merck), 50 μM ATP (Sigma) and 50 μM ADP (Sigma). Calcium imaging was conducted in the FLIPR Penta High-Throughput Cellular Screening System (Molecular Devices). Fluorescent changes were recorded every second and an output per well generated.

(2) How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a comparison of two protocolsResearch SquareOctober 29, 2023Anil Kumar Kalia, Corinna Rösseler, Rafael Granja-Vazquez, Ayesha Ahmad, Joseph J. Pancrazio, Anika Neureiter, Mei Zhang, Daniel Sauter, Irina Vetter, Asa Andersson, et al.(Olympus). FLIPR (high-throughput plate reader assays) For high-throughput fluorescent imaging assays using the FLIPRPenta (Molecular Devices), RealDRG™ were thawed and cultured in Senso-MM (Anatomic Incorporated). Cells were

(3) Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicityNature CommunicationsJuly 6, 2023Dengqin Zhong, Ruiyun Wang, Hongjing Zhang, Mengmeng Wang, Xuxia Zhang, Honghong ChenFluorescence intensity was recorded at excitation wavelength of 470 nm and emission wavelength of 516 nm by an FLIPR Penta high-throughput real-time fluorescence imaging analysis system (FLIPR) operated by FLIPR Penta (Molecular Devices

(4) Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 functionNature CommunicationsApril 28, 2023Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, et al.and incubated in the dark at 37 °C for 60 min. Changes in membrane potential were assessed using a FLIPRPenta (excitation, 515–545 nm; emission, 565–625 nm; Molecular Devices, California, USA) every 0.5 s for 10

(5) Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for MigrainePharmaceuticals (Basel)February 1, 2023Tino Dyhring, Inger Jansen-Olesen, Palle Christophersen, Jes OlesenAfter 1-h incubation at 37 °C in a humidified 5% CO2 environment, the plates were transferred to a FLIPR Penta (Molecular Devices, Sunnyvale, CA, USA). Both KATP channel activators and inhibitors were tested in

(6) Tritium Labeling of Neuromedin S by Conjugation with [3H]N-Succinimidyl PropionateACS OmegaJanuary 17, 2023Martin R. Edelmann, Johannes Erny, Wolfgang Guba, Markus Hierl5% CO2. All assays were performed using clear-bottom 384-well plates (Corning, Catalog 3764) on the FLIPR Penta (fluorescence imaging plate reader) from Molecular Devices (Sunnyvale, CA). The FLIPR Calcium 6 Assay

(7) High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensorsCommunications biologyNovember 12, 2022Kundu S, Boutin ME, Strong CE, Voss T, Ferrer M.cocultures, on 384 well plates, using a Calbryte 520AM dye (Fisher Scientific, NC1812243) with the FLIPR Penta High Throughput Cellular Screening System (Molecular Devices). First, 500 µL working solution of Calbryte 520AM was made with HHBS (Hank’sBuffer

(8) PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522The EMBO JournalSeptember 1, 2021Emily Maguire et al.control. Plates were warmed in a plate reader (Spectramax Gemini EM) or automated cell screening system (FLIPR Penta Molecular Devices) to 37°C and cells were exposed at set time points to anti‐FcγRII/III, LPS, oligomers

(9) G-protein activation by a metabotropic glutamate receptorNatureJuly 15, 2021Alpay B. Seven et al.the calcium response of mGlu2 was measured in a dose–response allosteric shift experiment, using a FLIPR Penta multi-well plate reader (Molecular Devices), with increasing concentrations of l-glutamate (ranging

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